Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD.

Brazilian research consortium on obsessive-compulsive spectrum disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: Cognitive-Behavior Therapy treatment.

OBJECTIVE: To summarize the evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). METHODS: A systematic review of the literature on CBT interventions for the treatment of adult OCD, comprising behavior therapy and exposure and response prevention (ERP) was done. The objective of this study is to present updated clinical guidelines to clinicians, providing comprehensive details regarding the necessary procedures to be incorporated into the CBT protocol. We searched the literature published from 2013-2020 in five databases (PubMed, Cochrane, Embase, Psycinfo and Lilacs), considering: study design, primary outcome measures, type of publication and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). RESULTS: We examined 44 new studies used to update the APA guidelines from 2013. High-quality evidence supports CBT including ERP techniques as the first-line CBT treatment for OCD. In addition, protocols for internet-delivered CBT have also demonstrated their efficacy for the treatment of adults with OCD. CONCLUSION: CBT based on ERP is a widely used treatment according to high-quality scientific evidence to treat adults with OCD.

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment.

OBJECTIVES: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). METHODS: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). RESULTS: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. CONCLUSION: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

Personality Inventory for DSM-5 (PID-5): cross-cultural adaptation and content validity in the Brazilian context / Inventário de Personalidade para o DSM-5 (PID-5): adaptação transcultural e validade de conteúdo para o contexto brasileiro

Abstract Objective To describe the process of cross-cultural adaptation of the Personality Inventory for DSM-5 (PID-5) to the Brazilian context. Methods Cross-cultural adaptation involved the steps of independent translation of the instrument, synthesis version, and back-translation. Analysis of content validity was conducted by a multidisciplinary expert committee and consisted of quantitative assessment of agreement indicators. The test was then applied to a target population. Results All the steps required for a cross-cultural adaptation were followed and satisfactory agreement values (≥ 4.75) were reached for most of the structures assessed. Most of the changes suggested by the experts were followed; these changes consisted primarily of adjustments to verb tense and agreement and the inclusion of letters and words to allow gender inflection. In the pre-test, no suggestions were made and the instrument was considered comprehensible. Conclusion The Brazilian version of the PID-5 was found to be adequate to the Brazilian context from semantic, idiomatic, cultural, and conceptual perspectives. The Brazilian version assessed here can be freely used, was approved by the publishers who hold the copyright on the instrument, and is considered the official version of the instrument. New studies are underway to determine the validity and reliability of the PID-5.

Resumo Objetivo Apresentar o processo de adaptação transcultural do Personality Inventory for DSM-5 (PID-5) para o contexto brasileiro. Métodos A adaptação transcultural envolveu as etapas de tradução independente, versão síntese e retrotradução. A validade de conteúdo foi realizada por um comitê multidisciplinar de especialistas, com avaliação quantitativa dos índices de concordância. Por fim, o pré-teste foi conduzido com a população-alvo. Resultados Todos os estágios da adaptação transcultural foram seguidos, e na maioria das estruturas avaliadas, os valores de concordância foram satisfatórios (≥ 4.75). Grande parte das sugestões de modificações feitas pelos especialistas foram acatadas, sendo as principais relacionadas a ajustes no tempo e concordância verbal e a inclusão de letras e palavras para permitir a flexão de gênero. No pré-teste nenhuma sugestão foi apresentada e o instrumento foi considerado compreensível. Conclusão A versão brasileira do PID-5 mostrou-se adequada ao contexto brasileiro sob as perspectivas semântica, idiomática, cultural e conceitual. A versão brasileira avaliada é de uso livre, foi aprovada pelas editoras responsáveis pelos direitos autorais do instrumento e é considerada oficial. Novos estudos estão sendo conduzidos para aprimorar a busca por evidencias de validade e confiabilidade.

Personality Inventory for DSM-5 (PID-5): cross-cultural adaptation and content validity in the Brazilian context.

OBJECTIVE: To describe the process of cross-cultural adaptation of the Personality Inventory for DSM-5 (PID-5) to the Brazilian context. METHODS: Cross-cultural adaptation involved the steps of independent translation of the instrument, synthesis version, and back-translation. Analysis of content validity was conducted by a multidisciplinary expert committee and consisted of quantitative assessment of agreement indicators. The test was then applied to a target population. RESULTS: All the steps required for a cross-cultural adaptation were followed and satisfactory agreement values (≥ 4.75) were reached for most of the structures assessed. Most of the changes suggested by the experts were followed; these changes consisted primarily of adjustments to verb tense and agreement and the inclusion of letters and words to allow gender inflection. In the pre-test, no suggestions were made and the instrument was considered comprehensible. CONCLUSION: The Brazilian version of the PID-5 was found to be adequate to the Brazilian context from semantic, idiomatic, cultural, and conceptual perspectives. The Brazilian version assessed here can be freely used, was approved by the publishers who hold the copyright on the instrument, and is considered the official version of the instrument. New studies are underway to determine the validity and reliability of the PID-5.

Ensinando a Anamnese Psiquiátrica para Estudantes de Medicina através da Inversão de Papéis: Relato de Experiência / Teaching Psychiatric Anamnesis to Medical Students through Role Reversal: Experience Report

RESUMO Introdução Tem havido um renovado interesse pela temática da relação médico-paciente e dos valores humanitários na formação dos estudantes de Medicina, pois a capacidade de sentir empatia pelos pacientes é considerada um dos pilares da boa prática médica. A inversão de papéis é uma técnica derivada do psicodrama que pode favorecer o desenvolvimento da capacidade empática na relação médico-paciente. Objetivo Relatar a experiência de ensino-aprendizagem da anamnese psiquiátrica no curso de Semiologia em Psiquiatria com alunos da terceira série do curso médico da Faculdade de Medicina de Botucatu (Unesp), utilizando a inversão de papéis como principal método pedagógico. Método Relato de experiência. A atividade é desenvolvida em cinco etapas distintas, mas inter-relacionadas: (1) leitura e estudo autônomos da apostila de propedêutica psiquiátrica; (2) realização da anamnese em três grupos de 15 alunos, em que estes alternam o papel de médico (entrevistador) e paciente (entrevistado); (3) realização de uma anamnese completa com um colega de turma, alternando-se também o papel de paciente e de médico; (4) realização, pela mesma dupla, da anamnese psiquiátrica com um paciente internado no hospital geral universitário; (5) discussão das anamneses realizadas, atividade em que os alunos assumem o papel do paciente entrevistado para relatar, em primeira pessoa, os dados obtidos na entrevista. Resultados Os alunos mostram-se colaborativos, participando com interesse de todas as etapas da atividade, que parece favorecer não apenas o aprendizado específico da anamnese psiquiátrica, mas também a capacidade empática pelos colegas e pacientes. Nas discussões, atenção especial é dada às descobertas e dificuldades vivenciadas pelos estudantes nessas atividades práticas, assim como aos sentimentos experimentados em cada uma das etapas do processo. A atitude do preceptor de ouvir e acolher com respeito todos os relatos, dúvidas e manifestações afetivas dos alunos procura ser um modelo de postura de acolhimento sem julgamento dos problemas e sentimentos dos pacientes, postura fundamental para o estabelecimento da aliança terapêutica. Conclusão A inversão de papéis pode auxiliar os estudantes de Medicina no aprendizado da anamnese psiquiátrica, assim como no desenvolvimento da empatia, habilidade essencial à prática médica de boa qualidade.

ABSTRACT Introduction There has been renewed interest in the doctor-patient relationship and humanitarian values in the training of medical students, given that the ability to feel empathy for patients is considered one of the pillars of good medical practice. Role reversal is a technique derived from Psychodrama that can promote the development of empathic capacity in the doctor-patient relationship. Objective to report a teaching-learning experience of psychiatric anamnesis in the course of Semiology in Psychiatry with 3rd year students of Botucatu Medical School (UNESP), using the technique of role reversal as the main pedagogical approach. Method experience report. The activity has been developed in five distinct but interrelated stages: 1) autonomous reading and studying the psychiatric propaedeutic courseware; 2) performing the anamnesis in three groups of 15 students, in which they alternate between the roles of physician (interviewer) and patient (interviewed); 3) performing a complete anamnesis with a classmate, also alternating the roles of patient and physician; 4) the same pair of students performs the psychiatric anamnesis with an inpatient of the general university hospital; 5) discussion of the anamneses performed, an activity in which the students assume the role of the patient, reporting, in the first person, the data obtained in the interview. Results the students have been collaborative, participating with interest in all stages of the activity, which seems to favour not only the specific learning of psychiatric anamnesis, but also their empathic capacity towards colleagues and patients. In the discussions, special attention has been given to the discoveries and difficulties experienced by the students in these practical activities, and the feelings experienced in each stage of the process. The preceptors' attitude of respectfully listening to and accepting all the reports, doubts and affective manifestations of the students provides a model for an accepting and non-judgemental attitude toward patients' problems and feelings, which is fundamental for the development of the therapeutic alliance. Conclusion Role reversal can be used to help medical students develop their skills in psychiatric anamnesis, and their empathy, an essential skill for good quality medical practice.

Depressive symptoms among the elderly in São Paulo city, Brazil: prevalence and associated factors (SABE Study). / Sintomas depressivos em idosos do município de São Paulo, Brasil: prevalência e fatores associados (Estudo SABE).

OBJECTIVE: To estimate the prevalence of depressive symptoms in the elderly in São Paulo city, Brazil (SABE Study), in 2006 and to identify risk factors associated with the 2006 prevalence and protective factors among those who did not have depressive symptoms in the assessments conducted in 2000 and 2006. METHODS: In this cross-sectional and longitudinal study, the Geriatric Depression Scale was used for inclusion in the cohort in 2000 and also in 2006. RESULTS: The prevalence of depressive symptoms in 2006 was 14.2% (95%CI 11.8 - 16.7), and 74.8% of the participants did not present depressive symptoms in 2000 neither in 2006. Logistic regression models were constructed, with different groups of variables (socio-demographic variables, status and perception of health and memory) adjusted for sex and age. In the final logistic regression model, the following factors were associated with depressive symptoms: self-assessment of vision, oral health, memory and of general health as poor, dependence for basic activities of daily living, and moderate or severe family dysfunction. Protective factors against presenting depressive symptoms in the 2000 and 2006 phases were: being male, absence of pulmonary disease and positive self-assessment of health. CONCLUSION: Depressive symptoms were frequent among the elderly, and were associated with health problems, dependence and family dysfunction. These factors should be addressed in health policy planning for the care of these elderly.

OBJETIVO: Estimar a prevalência de sintomas depressivos em idosos do município de São Paulo, Brasil (Estudo SABE), em 2006 e identificar fatores de risco associados a essa prevalência em 2006 e fatores de proteção entre os idosos que não apresentaram sintomas depressivos nas avaliações realizadas em 2000 e 2006. MÉTODOS: Estudo transversal e longitudinal que utilizou a Escala de Depressão Geriátrica na inclusão da coorte em 2000 e em 2006. RESULTADOS: A prevalência de sintomas depressivos em 2006 foi de 14,2% (IC95% 11,8 - 16,7) e 74,8% dos participantes não apresentaram sintomas depressivos em 2000 nem em 2006. Foram construídos modelos de regressão logística, tendo como exposição diferentes grupos de variáveis (sociodemográficas; condições e percepção de saúde e memória) ajustando-se para sexo e idade. No modelo final da regressão logística, associaram-se a sintomas depressivos: autoavaliação da visão, da saúde bucal, da memória e da saúde geral como ruins, dependência para atividades básicas de vida diária e disfunção familiar moderada ou grave. Os fatores de proteção para não ter apresentado sintomas depressivos nas fases de 2000 e 2006 foram: sexo masculino, não referir doença pulmonar e avaliar positivamente a saúde. CONCLUSÃO: Sintomas depressivos nos idosos estudados foram frequentes e se associaram com piores condições de saúde, dependência e disfunção familiar e tais fatores devem ser considerados no planejamento de políticas de saúde para prestação de cuidados a esses idosos.

Prevalence and correlates of common mental disorders among dental students in Brazil.

This study aimed to estimate prevalence of common mental disorders (CMD) and associated factors among dental students. In this cross-sectional study, 230 students answered a questionnaire and instruments to assess CMD (Self Reporting Questionnaire-20), hazardous alcohol consumption (Alcohol Use Disorder Identification Test), social support (Social Support Scale), perceptions of academic life (Dundee Ready Education Environment Measure), coping (Ways of Coping Inventory) and resilience (Resilience Scale). Bivariate analysis was conducted using the Chi-Square and Mann-Whitney tests. Logistic regression included all explanatory variableswith p<0.20 in the bivariate analysis, besides sex and academic year. The explanatory variables were analyzed in five successive blocks (backward-stepwise), until all variables presented statistical significance in the final model (p<0.05). The prevalence of CMD was 45.2% (95%CI: 38.7-51.6), with no significant differences between sexes. Students with no extracurricular activities, who had negatively self- assessed their health status and their academic performance, were about four times more likely to present CMD, followed by receiving psychological or psychiatric treatment during university (AOR: 2.65; 95%CI: 1.1-6.1) and those with high scores for confrontive coping (AOR: 1.20; 95%CI: 1.0-1.4). Resilience was a protective factor for CMD among dental students (AOR: 0.93; 95%CI: 0.9-1.0). Aspects related to academic performance, health status and confrontive coping strategies were risk factors to students' mental health. Individuals with high levels of resilience showed lower prevalence of CMD. Further prospective studies could contribute to understanding the role of resilience among this population.

Hazing and the Mental Health of Medical Students / O Trote e a Saúde Mental de Estudantes de Medicina

ABSTRACT Introduction: The practice of hazing is a phenomenon that began in the Middle Ages and persists in many universities around the world. In Brazil, although the problem is widely recognized, it has been insufficiently studied. Objective: To estimate the prevalence and to identify factors associated with the occurrence of hazing in a public Medical School, located in the interior of the State of São Paulo, Brazil. Method: A cross-sectional study was conducted, including 477 medical students from the first to the sixth year of the course. The self-reporting questionnaire included questions and structured instruments to access: socio-demographic and academic life characteristics, social support, symptoms of depression, harmful alcohol use (using the Alcohol Use Disorder Identification Test — Audit), common mental disorder (using the Self-Reporting Questionnaire — SRQ) and if the participant had suffered any form of hazing that he/she considered abusive or if the participant had practiced hazing about which he/she felt guilty or regretful afterwards. Bivariate analyses and logistic regression were conducted to identify factors independently associated with each of the outcomes (having suffered abusive hazing or having participated in hazing and feeling regretful afterwards). Results: The response rate was 87.0%. Among the students, 39.8% (95% Cl: 35.4% — 44.2%) reported having suffered abusive hazing, while 7.5% (95% CI: 5.2% — 9.9%) reported having practiced hazing of which they repented. Being subjected to abusive hazing was associated with: male gender, not being adapted to the city, presenting lower scores on the social support scale and psychiatric and/or psychological treatment after admission to university. Having practiced hazing, in turn, was associated with male gender, older age and higher score in the Audit. Conclusion: Hazing was associated with male gender, and with the pursuit of mental health treatment among those who received it and with harmful alcohol use among the perpetrators. It is essential that medical schools discuss and better understand the problem of hazing in order to adopt effective preventive measures.

RESUMO Introdução: A prática do trote é um fenômeno que teve início na Idade Média e ainda persiste em muitas universidades pelo mundo. No Brasil, embora seja um problema amplamente reconhecido, tem sido insuficientemente estudado. Objetivo: Estimar a prevalência e identificar fatores associados à ocorrência de trote numa faculdade de Medicina pública, localizada no interior do Estado de São Paulo. Método: Foi realizado um estudo transversal do qual participaram 477 estudantes de Medicina do primeiro ao sexto ano do curso. O questionário autopreenchido continha questões e instrumentos estruturados que permitiram avaliar: características sociodemográficas e da vida acadêmica, apoio social, sintomas depressivos, uso problemático de álcool (por meio do Alcohol Use Disorder Identification Test — Audit), transtorno mental comum (por meio do Self Reporting Questionnaire — SRQ) e se o participante sofreu trote que considerou abusivo ou se aplicou trote do qual se arrependeu posteriormente. Foi realizada análise bivariada e regressão logística para identificar fatores independentemente associados a cada um dos desfechos (ter sofrido trote que considerou abusivo ou ter aplicado trote do qual se arrependeu posteriormente). Resultados: A taxa de resposta foi de 87,0%. Relataram ter sofrido trote abusivo 39,8% (IC95% 35,4% — 44,2%) dos estudantes, enquanto afirmaram ter aplicado trote do qual se arrependeram 7,5% (IC95% 5,2% — 9,9%) deles. Ter sofrido trote abusivo associou-se a: sexo masculino, não estar adaptado à cidade, apresentar menor escore na escala de apoio social e ter feito ou estar fazendo tratamento psiquiátrico e/ou psicológico após o ingresso na universidade. Ter aplicado trote, por sua vez, também se associou a sexo masculino, assim como a maior idade e maior pontuação no Audit. Conclusão: Trote associou-se a sexo masculino e à procura por tratamento de saúde mental entre os que o receberam e a uso problemático de álcool entre os que o praticaram. É fundamental que as instituições debatam e compreendam melhor o problema do trote, a fim de adotar medidas efetivas para que este seja prevenido.

Sintomas depressivos em idosos do município de São Paulo, Brasil: prevalência e fatores associados (Estudo SABE) / Depressive symptoms among the elderly in São Paulo city, Brazil: prevalence and associated factors (SABE Study)

RESUMO: Objetivo: Estimar a prevalência de sintomas depressivos em idosos do município de São Paulo, Brasil (Estudo SABE), em 2006 e identificar fatores de risco associados a essa prevalência em 2006 e fatores de proteção entre os idosos que não apresentaram sintomas depressivos nas avaliações realizadas em 2000 e 2006. Métodos: Estudo transversal e longitudinal que utilizou a Escala de Depressão Geriátrica na inclusão da coorte em 2000 e em 2006. Resultados: A prevalência de sintomas depressivos em 2006 foi de 14,2% (IC95% 11,8 - 16,7) e 74,8% dos participantes não apresentaram sintomas depressivos em 2000 nem em 2006. Foram construídos modelos de regressão logística, tendo como exposição diferentes grupos de variáveis (sociodemográficas; condições e percepção de saúde e memória) ajustando-se para sexo e idade. No modelo final da regressão logística, associaram-se a sintomas depressivos: autoavaliação da visão, da saúde bucal, da memória e da saúde geral como ruins, dependência para atividades básicas de vida diária e disfunção familiar moderada ou grave. Os fatores de proteção para não ter apresentado sintomas depressivos nas fases de 2000 e 2006 foram: sexo masculino, não referir doença pulmonar e avaliar positivamente a saúde. Conclusão: Sintomas depressivos nos idosos estudados foram frequentes e se associaram com piores condições de saúde, dependência e disfunção familiar e tais fatores devem ser considerados no planejamento de políticas de saúde para prestação de cuidados a esses idosos.

ABSTRACT: Objective: To estimate the prevalence of depressive symptoms in the elderly in São Paulo city, Brazil (SABE Study), in 2006 and to identify risk factors associated with the 2006 prevalence and protective factors among those who did not have depressive symptoms in the assessments conducted in 2000 and 2006. Methods: In this cross-sectional and longitudinal study, the Geriatric Depression Scale was used for inclusion in the cohort in 2000 and also in 2006. Results: The prevalence of depressive symptoms in 2006 was 14.2% (95%CI 11.8 - 16.7), and 74.8% of the participants did not present depressive symptoms in 2000 neither in 2006. Logistic regression models were constructed, with different groups of variables (socio-demographic variables, status and perception of health and memory) adjusted for sex and age. In the final logistic regression model, the following factors were associated with depressive symptoms: self-assessment of vision, oral health, memory and of general health as poor, dependence for basic activities of daily living, and moderate or severe family dysfunction. Protective factors against presenting depressive symptoms in the 2000 and 2006 phases were: being male, absence of pulmonary disease and positive self-assessment of health. Conclusion: Depressive symptoms were frequent among the elderly, and were associated with health problems, dependence and family dysfunction. These factors should be addressed in health policy planning for the care of these elderly.

O Trote e a Saúde Mental de Estudantes de Medicina / Hazing and the Mental Health of Medical Students

RESUMO Introdução A prática do trote é um fenômeno que teve início na Idade Média e ainda persiste em muitas universidades pelo mundo. No Brasil, embora seja um problema amplamente reconhecido, tem sido insuficientemente estudado. Objetivo Estimar a prevalência e identificar fatores associados à ocorrência de trote numa faculdade de Medicina pública, localizada no interior do Estado de São Paulo. Método Foi realizado um estudo transversal do qual participaram 477 estudantes de Medicina do primeiro ao sexto ano do curso. O questionário autopreenchido continha questões e instrumentos estruturados que permitiram avaliar: características sociodemográficas e da vida acadêmica, apoio social, sintomas depressivos, uso problemático de álcool (por meio do Alcohol Use Disorder Identification Test - Audit), transtorno mental comum (por meio do Self Reporting Questionnaire - SRQ) e se o participante sofreu trote que considerou abusivo ou se aplicou trote do qual se arrependeu posteriormente. Foi realizada análise bivariada e regressão logística para identificar fatores independentemente associados a cada um dos desfechos (ter sofrido trote que considerou abusivo ou ter aplicado trote do qual se arrependeu posteriormente). Resultados A taxa de resposta foi de 87,0%. Relataram ter sofrido trote abusivo 39,8% (IC95% 35,4% - 44,2%) dos estudantes, enquanto afirmaram ter aplicado trote do qual se arrependeram 7,5% (IC95% 5,2% - 9,9%) deles. Ter sofrido trote abusivo associou-se a: sexo masculino, não estar adaptado à cidade, apresentar menor escore na escala de apoio social e ter feito ou estar fazendo tratamento psiquiátrico e/ou psicológico após o ingresso na universidade. Ter aplicado trote, por sua vez, também se associou a sexo masculino, assim como a maior idade e maior pontuação no Audit. Conclusão Trote associou-se a sexo masculino e à procura por tratamento de saúde mental entre os que o receberam e a uso problemático de álcool entre os que o praticaram. É fundamental que as instituições debatam e compreendam melhor o problema do trote, a fim de adotar medidas efetivas para que este seja prevenido.

ABSTRACT Introduction The practice of hazing is a phenomenon that began in the middle ages and persists in many universities around the world. In Brazil, although the problem is widely recognized, it has been insufficiently studied. Objective To estimate the prevalence of hazing among medical students of a public university in São Paulo state - Brazil, and investigate factors associated with this problem. Method A cross-sectional study was conducted, including 477 medical students from the first to the sixth year of the course. The self-reporting questionnaire included questions and structured instruments to access: socio-demographic characteristics, aspects of academic life, social support, symptoms of depression, harmful alcohol use (using the Alcohol Use Disorder Identification Test - AUDIT), common mental disorder (using the Self-Reporting Questionnaire - SRQ), whether the participant had suffered any form of hazing that he/she considered abusive or whether the participant had practiced hazing about which he/she felt guilty or regretful afterwards. Bivariate analyses were conducted, followed by logistic regression analyses to identify independent predictors of these two outcomes (having suffered abusive hazing or having participated in hazing and feeling regretful afterwards). Results The response rate was 87.0%. Among the participants, 39.8% (95% CI: 35.4% - 44.2%) reported having suffered abusive hazing and 7.5% (95% CI: 5.2% - 9.9%) reported having practiced hazing. Those who reported having suffered abusive hazing were more likely to be male, to report difficulties in adaptation to the city, lower social support and psychiatric and/or psychological treatment after entering university. Those who practiced hazing and felt regretful afterwards were also more likely to be male, were older and presented higher mean scores in the AUDIT. Conclusion Hazing was associated with the male sex and mental health treatment among the victims, and with harmful alcohol use among the perpetrators. It is essential that medical schools discuss and better understand the problem of hazing in order to adopt effective preventive measures.

Burden and Distress in Caregivers of Patients With Panic Disorder and Agoraphobia.

We estimated the prevalence, severity, and correlates of burden and distress in caregivers of patients with panic disorder and agoraphobia. The instruments used in this cross-sectional study with 40 caregivers and 40 outpatients were Carer Burden Interview (CBI), Family Burden Interview Schedule (FBIS-BR), Self-Reporting Questionnaire (SRQ), Panic and Agoraphobia Scale (PAS), and Mini-international Neuropsychiatric Interview. Bivariate analyses were followed by regression analyses. The patients' mean PAS score was 29.6, and the mean scores in the caregivers' burden scales were 27 (CBI) and 1.64 (FBIS-BR). Distress (or common mental disorder [CMD]) occurred in 37.5% and was associated with higher burden. In the multivariate analysis, the SRQ score was predicted by female sex and worse self-evaluation of health, the CBI score by CMD and public service, the FBIS-BR score by CMD and not living with the patient, the FBIS-objective score by CMD and being employed, the FBIS-subjective score by CMD, and the level of worry by the severity of patients' avoidance and panic attacks.

Social anxiety symptoms in alcohol-dependent outpatients: prevalence, severity and predictors / Sintomas de ansiedade social em alcoolistas em tratamento ambulatorial: prevalência, gravidade e preditores

ABSTRACT Objectives High rates of comorbidity between social anxiety disorder (SAD) and alcohol use disorders have been reported, but the predictors of this comorbidity are poorly known and most studies involve primary SAD samples. The aims were to estimate the prevalence and severity of SAD symptoms among alcohol-dependent patients and to investigate sociodemographic and clinical factors associated with SAD comorbidity, including suicidal behaviors. Methods A cross-sectional study with 53 adults who were in treatment for alcohol dependence at a Brazilian public university outpatient service. Assessment instruments Social Phobia Inventory (SPIN), Short Alcohol Dependence Data and Beck Depression Inventory. Bivariate analyses between the categorical outcome (Probable SAD: SPIN ≥ 19) and explanatory variables were conducted. Correlates of SPIN total and subscales scores (dimensional outcomes) were also investigated. Results The diagnosis and treatment of alcohol dependence occurred, on average, 30 years after the onset of alcohol use and 39.6% of the 53 patients (37 men and 16 women) reported alleviation of social anxiety symptoms with alcohol use. Twenty-four (45.3%) patients presented probable SAD. These patients differed from non-SAD alcohol-dependent individuals by having lower income and higher frequency of depression, suicidal ideation, suicide plans and attempts. The SPIN subscales mostly associated with suicidal behaviors were social inadequacy and social inferiority. Conclusions SAD symptoms are common among help-seeking alcohol-dependent individuals and should be directly investigated and treated, since depression and suicidality are associated with this comorbidity. Prospective studies are needed to assess the impact of SAD treatment on the clinical course of alcohol dependence.

RESUMO Objetivos Altas taxas de comorbidade têm sido descritas entre o transtorno de ansiedade social (TAS) e os transtornos por uso de álcool, mas os preditores dessa comorbidade são pouco conhecidos, e a maioria dos estudos envolve pacientes com diagnóstico primário de TAS. Os objetivos foram estimar a prevalência e a gravidade de sintomas de TAS em pacientes dependentes de álcool e investigar fatores sociodemográficos e clínicos associados à comorbidade com TAS, incluindo risco de suicídio. Métodos Estudo transversal com 53 adultos em tratamento ambulatorial para dependência de álcool num hospital público universitário brasileiro. Instrumentos de avaliação: Social Phobia Inventory (SPIN), Short Alcohol Dependence Data e Beck Depression Inventory. Foram conduzidas análises bivariadas entre o desfecho categorial (provável TAS: SPIN ≥ 19) e as variáveis explanatórias. Correlatos dos escores total e das subescalas da SPIN (desfechos dimensionais) também foram investigados. Resultados O diagnóstico e o tratamento da dependência de álcool ocorreram em média 30 anos após o início do uso de álcool, e 39,6% dos 53 pacientes (37 homens e 16 mulheres) relataram alívio dos sintomas de ansiedade social com o uso de álcool. Vinte e quatro (45,3%) pacientes apresentaram provável TAS. Esses pacientes diferiram dos alcoolistas sem TAS, por terem menor renda, maior frequência de depressão, ideação suicida, planos e tentativas de suicídio. As subescalas da SPIN que mais se associaram com comportamentos suicidas foram inadequação social e inferioridade social. Conclusões Sintomas de TAS são comuns em alcoolistas em tratamento e devem ser diretamente investigados e tratados, já que depressão e suicidalidade associam-se com essa comorbidade. Estudos prospectivos são necessários para investigar o impacto do tratamento do TAS no curso clínico da dependência de álcool.

Obsessive-compulsive symptoms among alcoholics in outpatient treatment: Prevalence, severity and correlates.

The literature on symptoms of obsessive-compulsive disorder (OCD) in alcoholic patients is scarce and such symptoms can go unnoticed, worsening the prognosis of alcoholism. The objectives were to estimate the prevalence and severity of obsessive-compulsive symptoms in alcoholics undergoing outpatient treatment and to assess sociodemographic and clinical correlates, including suicidal behaviors. The instruments used in this cross-sectional study were the Obsessive-Compulsive Inventory - Revised (OCI-R), the Short Alcohol Dependence Data and the Beck Depression Inventory. After descriptive analyses, bivariate analyses between the categorical ("probable OCD": OCI-R≥27) and dimensional (OCI-R total and subscales scores) outcomes and all explanatory variables were conducted. Eleven (20.4%) of the 54 alcoholic patients (37 men and 17 women) presented "probable OCD", which was associated with lower income, more severe dependence, depression, lifetime suicidal thoughts and plans and suicide attempts. OCI-R severity (mean 16.0) was associated with the same predictors and with psychiatric hospitalization. Suicidal behaviors were mainly associated with the Obsession, Hoarding and Washing subscales. It is essential to investigate and treat OCD symptoms in alcoholics, as they are associated with greater severity of dependence, depression and suicidal behaviors. Longitudinal studies are required to assess the impact of OCD treatment on the clinical course of alcoholism.

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates.

INTRODUCTION: It is important to understand the characteristics and vulnerabilities of people who have hepatitis C because this disease is currently an important public health problem. The objective of this study was to estimate the prevalence of depressive symptoms and harmful alcohol use in patients with hepatitis C and to study the association between these outcomes and demographic, psychosocial and clinical variables. METHODS: This cross-sectional, descriptive and analytical study involved 82 hepatitis C patients who were being treated with pegylated interferon and ribavirin at a public university hospital. The primary assessments used in the study were the Alcohol Use Disorders Identification Test and the Beck Depression Inventory. Bivariate analyses were followed by logistic regression. RESULTS: The prevalence of depressive symptoms was 30.5% (n=25), and that of harmful alcohol use was 34.2% (n=28). Logistic regression analysis showed that individuals who were dissatisfied with their social support (OR=4.41; CI=1.00-19.33) and were unemployed (OR=6.31; CI=1.44-27.70) were at a higher risk for depressive symptoms, whereas harmful alcohol use was associated with the male sex (OR=6.78; CI=1.38-33.19) and the use of illicit substances (OR=7.42; CI=1.12-49.00). CONCLUSIONS: High prevalence rates of depressive symptoms and harmful alcohol use were verified, indicating vulnerabilities that must be properly monitored and treated to reduce emotional suffering in this population.

Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Introduction It is important to understand the characteristics and vulnerabilities of people who have hepatitis C because this disease is currently an important public health problem. The objective of this study was to estimate the prevalence of depressive symptoms and harmful alcohol use in patients with hepatitis C and to study the association between these outcomes and demographic, psychosocial and clinical variables. Methods This cross-sectional, descriptive and analytical study involved 82 hepatitis C patients who were being treated with pegylated interferon and ribavirin at a public university hospital. The primary assessments used in the study were the Alcohol Use Disorders Identification Test and the Beck Depression Inventory. Bivariate analyses were followed by logistic regression. Results The prevalence of depressive symptoms was 30.5% (n=25), and that of harmful alcohol use was 34.2% (n=28). Logistic regression analysis showed that individuals who were dissatisfied with their social support (OR=4.41; CI=1.00-19.33) and were unemployed (OR=6.31; CI=1.44-27.70) were at a higher risk for depressive symptoms, whereas harmful alcohol use was associated with the male sex (OR=6.78; CI=1.38-33.19) and the use of illicit substances (OR=7.42; CI=1.12-49.00). Conclusions High prevalence rates of depressive symptoms and harmful alcohol use were verified, indicating vulnerabilities that must be properly monitored and treated to reduce emotional suffering in this population. .

Social phobia in obsessive-compulsive disorder: prevalence and correlates.

BACKGROUND: Social Phobia (SP) is an anxiety disorder that frequently co-occurs with obsessive-compulsive disorder (OCD); however, studies that evaluate clinical factors associated with this specific comorbidity are rare. The aim was to estimate the prevalence of SP in a large multicenter sample of OCD patients and compare the characteristics of individuals with and without SP. METHOD: A cross-sectional study with 1001 patients of the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders using several assessment instruments, including the Dimensional Yale-Brown Obsessive-Compulsive Scale and the Structured Clinical Interview for DSM-IV Axis I Disorders. Univariate analyses were followed by logistic regression. RESULTS: Lifetime prevalence of SP was 34.6% (N=346). The following variables remained associated with SP comorbidity after logistic regression: male sex, lower socioeconomic status, body dysmorphic disorder, specific phobia, dysthymia, generalized anxiety disorder, agoraphobia, Tourette syndrome and binge eating disorder. LIMITATIONS: The cross-sectional design does not permit the inference of causal relationships; some retrospective information may have been subject to recall bias; all patients were being treated in tertiary services, therefore generalization of the results to other samples of OCD sufferers should be cautious. Despite the large sample size, some hypotheses may not have been confirmed due to the small number of cases with these characteristics (type 2 error). CONCLUSION: SP is frequent among OCD patients and co-occurs with other disorders that have common phenomenological features. These findings have important implications for clinical practice, indicating the need for broader treatment approaches for individuals with this profile.

Dimensional analysis of burden in family caregivers of patients with obsessive-compulsive disorder.

AIMS: Obsessive-compulsive disorder (OCD) also generates emotional burden in the patient's family members, but no study has evaluated the specific dimensions of burden. The objectives were to evaluate the dimensions of the Zarit Burden Interview (ZBI) and possible correlates. METHODS: This was a cross-sectional study involving 47 patients and 47 caregivers, using a sociodemographic questionnaire; the ZBI; the Self Reporting Questionnaire; the Family Accommodation Scale; and the Yale-Brown Obsessive-Compulsive Scale. The ZBI factor analysis was conducted using Varimax Rotation. RESULTS: Six factors were identified, explaining 74.2% of the total variance: factor 1, interference in the caregiver's personal life (36.6% of the variance); factor 2, perception of patient's dependence (10.8%); factor 3, feelings of irritation or intolerance (9.2%); factor 4, guilt (7.2%); factor 5, insecurity (5.6%); and factor 6, embarrassment (4.8%). The six ZBI factors were associated with greater OCD severity and with greater accommodation to the patient's symptoms, and factors 1, 2, 5 and 6 with caregiver's psychological morbidity. Caregiver's sex (female) was associated with factors 5 and 6, relationship with the patient (being a parent or son/daughter) with factor 5, higher educational level with factor 6, living with the patient with factor 3, worse self-evaluation of health with factors 1, 5 and 6, and occupational status (not working) with factors 1, 2, 5 and 6. CONCLUSION: The dimensions of burden identified indicate the most affected aspects of a caregiver's life and could guide the planning of more specific interventions. Thus, the caregiver could participate more effectively in the OCD patient's treatment, with a lower impact on his/her life.

Clinical correlates of social adjustment in patients with obsessive-compulsive disorder.

BACKGROUND: Patients with obsessive-compulsive disorder (OCD) frequently show poor social adjustment, which has been associated with OCD severity. Little is known about the effects that age at symptom onset, specific OCD symptoms, and psychiatric comorbidities have on social adjustment. The objective of this study was to investigate the clinical correlates of social functioning in OCD patients. METHODS: Cross-sectional study involving 815 adults with a primary DSM-IV diagnosis of OCD participating in the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders. Patients were assessed with the Social Adjustment Scale, the Medical Outcomes Study 36-item Short-Form Health Survey, the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Clinical correlates of social adjustment were assessed with generalized linear models with gamma distribution. RESULTS: Poor overall social functioning was associated with greater OCD severity (p = 0.02); hoarding symptoms (p = 0.004); sexual/religious obsessions (p = 0.005); current major depressive disorder (p = 0.004); current post-traumatic stress disorder (p = 0.002); and current eating disorders (p = 0.02). Poor social adjustment was also associated with impaired quality of life. CONCLUSIONS: Patients with OCD have poor social functioning in domains related to personal relationships and professional performance. Hoarding symptoms and sexual/religious obsessions seem to have the strongest negative effects on social functioning. Early age at OCD symptom onset seems to be associated with professional and academic underachievement and impairment within the family unit, whereas current psychiatric comorbidity worsen overall social functioning. In comparison with quality of life, social adjustment measures seem to provide a more comprehensive overview of the OCD-related burden.